Diabetes-induced rat tracheal segment supersensitivity to carbachol.
Can J Physiol Pharmacol
; 66(5): 660-2, 1988 May.
Article
em En
| MEDLINE
| ID: mdl-3046719
ABSTRACT
Contractile responses to carbachol of tracheal segments isolated (i) from rats made diabetic 4 months prior by a single intravenous injection (50 mg/kg) of streptozotocin (group B), and (ii) from diabetic rats that had been treated during the same period with a daily dose (2-4 U/animal) of long-acting insulin (group C) were compared with the contractile responses of trachea isolated from age-matched control animals (group A). Tracheal segments from group B were significantly more responsive to carbachol than those from group A or C at low, but not at high carbachol concentrations. Carbachol pD2 values were higher in group B (6.85 +/- 0.05) than in groups A (6.46 +/- 0.07) or C (6.37 +/- 0.06), but were not significantly different between groups A and C. These data indicate that diabetes induces a supersensitivity to carbachol in airway smooth muscles, possibly related to a diabetes-induced vagal autonomic neuropathy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traqueia
/
Carbacol
/
Diabetes Mellitus Experimental
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article