Curcumin prevents cigarette smoke extract induced cognitive impairment.
Front Biosci (Elite Ed)
; 11(1): 109-120, 2019 01 01.
Article
em En
| MEDLINE
| ID: mdl-30468642
ABSTRACT
Curcumin is a major phytochemical constituent in Curcuma longa, an herbaceous perennial plant of Zingiberaceae family, which exhibits anti-oxidant, anti-inflammatory and immunomodulatory properties. Here, we studied the therapeutic action of curcumin against CSE induced cognitive impairment in zebrafish. Montelukast (20 mg/kg), a cysteinyl-leukotriene receptor blocker was used as a reference drug. CSE exposure induced biochemical changes revealed that raise the brain acetylcholinesterase activity and lipid peroxidative products; and decrease the reduced glutathione levels in brain samples. Curcumin also protected against CSE induced neurocognitive impairment. These data suggest that curcumin can serve as a phytochemical constituent against CSE induced neurocognitive impairment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Extratos Vegetais
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Fármacos Neuroprotetores
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Curcumina
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Produtos do Tabaco
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article