Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-&#954;B, Nrf2, and PPAR-Î³ signaling pathways.

Lee, Eun-Jung; Park, Jin-Sun; Lee, Yu-Young; Kim, Do-Yeon; Kang, Jihee Lee; Kim, Hee-Sun

Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-κB, Nrf2, and PPAR-Î³ signaling pathways.

Lee, Eun-Jung; Park, Jin-Sun; Lee, Yu-Young; Kim, Do-Yeon; Kang, Jihee Lee; Kim, Hee-Sun.

Afiliação

Lee EJ; Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Mok-6-dong 911-1, Yangchun-Ku, Seoul, 158-710, South Korea.
Park JS; Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Mok-6-dong 911-1, Yangchun-Ku, Seoul, 158-710, South Korea.
Lee YY; Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Mok-6-dong 911-1, Yangchun-Ku, Seoul, 158-710, South Korea.
Kim DY; Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Mok-6-dong 911-1, Yangchun-Ku, Seoul, 158-710, South Korea.
Kang JL; Department of Physiology, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.
Kim HS; Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Mok-6-dong 911-1, Yangchun-Ku, Seoul, 158-710, South Korea. hskimp@ewha.ac.kr.

J Neuroinflammation ; 15(1): 326, 2018 Nov 23.

Article em En | MEDLINE | ID: mdl-30470240

Assuntos

Astrócitos/efeitos dos fármacos; Inibidores Enzimáticos/farmacologia; Regulação da Expressão Gênica/efeitos dos fármacos; Metaloproteinase 8 da Matriz/metabolismo; Peptídeos/farmacologia; Transdução de Sinais/efeitos dos fármacos; Animais; Animais Recém-Nascidos; Peptídeos Catiônicos Antimicrobianos; Células Cultivadas; Córtex Cerebral/citologia; Citocininas/genética; Citocininas/metabolismo; Ensaio de Desvio de Mobilidade Eletroforética; Lipopolissacarídeos/farmacologia; Fator 2 Relacionado a NF-E2/metabolismo; NF-kappa B/metabolismo; Nitritos/metabolismo; Receptores Ativados por Proliferador de Peroxissomo/metabolismo; Ratos; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/metabolismo; Ácidos Teicoicos/farmacologia

Palavras-chave

Anti-inflammatory; Antioxidant; Astrocytes; MMP-8 inhibitor; Molecular mechanisms; Neuroinflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Transdução de Sinais / Regulação da Expressão Gênica / Astrócitos / Metaloproteinase 8 da Matriz / Inibidores Enzimáticos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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