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JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation.
Czech, Julia; Cordua, Sabrina; Weinbergerova, Barbora; Baumeister, Julian; Crepcia, Assja; Han, Lijuan; Maié, Tiago; Costa, Ivan G; Denecke, Bernd; Maurer, Angela; Schubert, Claudia; Feldberg, Kristina; Gezer, Deniz; Brümmendorf, Tim H; Müller-Newen, Gerhard; Mayer, Jiri; Racil, Zdenek; Kubesova, Blanka; Knudsen, Trine; Sørensen, Anders L; Holmström, Morten; Kjær, Lasse; Skov, Vibe; Larsen, Thomas Stauffer; Hasselbalch, Hans C; Chatain, Nicolas; Koschmieder, Steffen.
Afiliação
  • Czech J; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Cordua S; Department of Hematology, Zealand University Hospital, Copenhagen University Hospital, Roskilde, Denmark.
  • Weinbergerova B; Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
  • Baumeister J; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Crepcia A; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Han L; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Maié T; Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen University, Aachen, Germany.
  • Costa IG; Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen University, Aachen, Germany.
  • Denecke B; Interdisciplinary Center for Clinical Research Aachen Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Maurer A; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Schubert C; Institute of Pathology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Feldberg K; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Gezer D; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Brümmendorf TH; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Müller-Newen G; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Mayer J; Institute of Biochemistry and Molecular Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
  • Racil Z; Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
  • Kubesova B; Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
  • Knudsen T; Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
  • Sørensen AL; Department of Hematology, Zealand University Hospital, Copenhagen University Hospital, Roskilde, Denmark.
  • Holmström M; Department of Hematology, Zealand University Hospital, Copenhagen University Hospital, Roskilde, Denmark.
  • Kjær L; Department of Hematology, Zealand University Hospital, Copenhagen University Hospital, Roskilde, Denmark.
  • Skov V; Department of Hematology, Zealand University Hospital, Copenhagen University Hospital, Roskilde, Denmark.
  • Larsen TS; Department of Hematology, Zealand University Hospital, Copenhagen University Hospital, Roskilde, Denmark.
  • Hasselbalch HC; Department of Hematology, Odense University Hospital, Odense, Denmark.
  • Chatain N; Department of Hematology, Zealand University Hospital, Copenhagen University Hospital, Roskilde, Denmark.
  • Koschmieder S; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Leukemia ; 33(4): 995-1010, 2019 04.
Article em En | MEDLINE | ID: mdl-30470838
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon-alfa / Calreticulina / Fator de Transcrição STAT1 / Janus Quinase 1 / Janus Quinase 2 / Mutação / Transtornos Mieloproliferativos Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon-alfa / Calreticulina / Fator de Transcrição STAT1 / Janus Quinase 1 / Janus Quinase 2 / Mutação / Transtornos Mieloproliferativos Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article