Improvement of microvascular endothelial dysfunction induced by exercise and diet is associated with microRNA-126 in obese adolescents.
Microvasc Res
; 123: 86-91, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30472037
ABSTRACT
OBJECTIVE:
Microvascular endothelial dysfunction, which is at the early stage of atherosclerosis, precedes macrovascular endothelial dysfunction. The study is aimed to investigate the mechanism underlying the improvement of microvascular endothelial dysfunction by exercise and diet in obese adolescents.METHODS:
A quasi-randomized study was carried out with 2 cohorts the experimental group (57 obese male adolescents; age 15.38⯱â¯2.82â¯years, BMI 33.21⯱â¯4.23â¯kg/m2) completed a 6-week exercise program with dietary intervention, and control group (10 normal weight adolescents; age 15.38⯱â¯2.82â¯years, BMI 23.21⯱â¯4.23â¯kg/m2) maintained sedentary. Clinical characteristics, circulating NO, ET-1 and microRNA-126 (miR-126) levels were measured before and after 6â¯weeks. The Reactive Hyperemia Index (RHI) was measured using EndoPAT-2000 system.RESULTS:
After 6-weeks intervention, obese adolescents' body circumferences and glucolipid metabolism are significantly improved. RHI (pâ¯<â¯0.01) and serum levels of NO/ET-1 (pâ¯<â¯0.01) are significantly increased, while microRNA-126 significantly decreased (pâ¯<â¯0.01). ΔMiR-126 were positive correlated with ΔBMI (râ¯=â¯0.60, pâ¯<â¯0.01), ΔRHI (râ¯=â¯0.69, pâ¯<â¯0.05), and ΔNO/ET-1 (râ¯=â¯-0.68, pâ¯<â¯0.05).CONCLUSIONS:
Combination of exercise and diet control can effectively improve glycolipid metabolism of obese adolescents, and thus their microvascular endothelial function, which might be related to changes in serum miRNA-126.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
MicroRNAs
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Restrição Calórica
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Terapia por Exercício
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Microvasos
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Obesidade Infantil
/
Hemodinâmica
Tipo de estudo:
Clinical_trials
/
Risk_factors_studies
Limite:
Adolescent
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Child
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Humans
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article