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The Smc5/6 Complex: New and Old Functions of the Enigmatic Long-Distance Relative.
Aragón, Luis.
Afiliação
  • Aragón L; Cell Cycle Group, MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, London W12 0NN, United Kingdom; email: luis.aragon@lms.mrc.ac.uk.
Annu Rev Genet ; 52: 89-107, 2018 11 23.
Article em En | MEDLINE | ID: mdl-30476445
Smc5 and Smc6, together with the kleisin Nse4, form the heart of the enigmatic and poorly understood Smc5/6 complex, which is frequently viewed as a cousin of cohesin and condensin with functions in DNA repair. As novel functions for cohesin and condensin complexes in the organization of long-range chromatin architecture have recently emerged, new unsuspected roles for Smc5/6 have also surfaced. Here, I aim to provide a comprehensive overview of our current knowledge of the Smc5/6 complex, including its long-established function in genome stability, its multiple roles in DNA repair, and its recently discovered connection to the transcription inhibition of hepatitis B virus genomes. In addition, I summarize new research that is beginning to tease out the molecular details of Smc5/6 structure and function, knowledge that will illuminate the nuclear activities of Smc5/6 in the stability and dynamics of eukaryotic genomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relação Estrutura-Atividade / Proteínas de Ciclo Celular / Proteínas de Schizosaccharomyces pombe / Complexos Multiproteicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relação Estrutura-Atividade / Proteínas de Ciclo Celular / Proteínas de Schizosaccharomyces pombe / Complexos Multiproteicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article