The Smc5/6 Complex: New and Old Functions of the Enigmatic Long-Distance Relative.
Annu Rev Genet
; 52: 89-107, 2018 11 23.
Article
em En
| MEDLINE
| ID: mdl-30476445
Smc5 and Smc6, together with the kleisin Nse4, form the heart of the enigmatic and poorly understood Smc5/6 complex, which is frequently viewed as a cousin of cohesin and condensin with functions in DNA repair. As novel functions for cohesin and condensin complexes in the organization of long-range chromatin architecture have recently emerged, new unsuspected roles for Smc5/6 have also surfaced. Here, I aim to provide a comprehensive overview of our current knowledge of the Smc5/6 complex, including its long-established function in genome stability, its multiple roles in DNA repair, and its recently discovered connection to the transcription inhibition of hepatitis B virus genomes. In addition, I summarize new research that is beginning to tease out the molecular details of Smc5/6 structure and function, knowledge that will illuminate the nuclear activities of Smc5/6 in the stability and dynamics of eukaryotic genomes.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Relação Estrutura-Atividade
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Proteínas de Ciclo Celular
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Proteínas de Schizosaccharomyces pombe
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Complexos Multiproteicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article