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Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases.
Kochetkova, Elena Y; Blinova, Galina I; Bystrova, Olga A; Martynova, Marina G; Pospelov, Valeriy A; Pospelova, Tatiana V.
Afiliação
  • Kochetkova EY; Institute of Cytology, Russian Academy of Sciences, St-Petersburg 194064, Russia.
  • Blinova GI; Institute of Cytology, Russian Academy of Sciences, St-Petersburg 194064, Russia.
  • Bystrova OA; Institute of Cytology, Russian Academy of Sciences, St-Petersburg 194064, Russia.
  • Martynova MG; Institute of Cytology, Russian Academy of Sciences, St-Petersburg 194064, Russia.
  • Pospelov VA; Institute of Cytology, Russian Academy of Sciences, St-Petersburg 194064, Russia.
  • Pospelova TV; Institute of Cytology, Russian Academy of Sciences, St-Petersburg 194064, Russia.
Aging (Albany NY) ; 10(11): 3574-3589, 2018 11 27.
Article em En | MEDLINE | ID: mdl-30482887
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Senescência Celular / Apoptose / MAP Quinase Quinase Quinases / MAP Quinases Reguladas por Sinal Extracelular / Alvo Mecanístico do Complexo 1 de Rapamicina Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Senescência Celular / Apoptose / MAP Quinase Quinase Quinases / MAP Quinases Reguladas por Sinal Extracelular / Alvo Mecanístico do Complexo 1 de Rapamicina Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article