Association Between c-Myc and Colorectal Cancer Prognosis: A Meta-Analysis.
Front Physiol
; 9: 1549, 2018.
Article
em En
| MEDLINE
| ID: mdl-30483143
ABSTRACT
Background:
There is debate as to whether c-Myc predicts prognosis in colorectal cancer (CRC). In this study, we aimed to review the association between c-Myc and CRC prognosis.Methods:
Pertinent studies were identified by searching electronic databases and carefully reviewing the reference lists of pertinent studies until March 2016. The summary hazard ratio (HR) and corresponding 95% confidence interval (CI) were calculated to study the association between c-Myc and CRC prognosis.Results:
Eight cohort studies (including seven studies about overall survival [OS] and one study about disease free survival [DFS]) were included. The pooled HR of OS was 1.13 (95% CI 0.66-1.95). In subgroup analysis, no significant association between c-Myc and CRC prognosis was found in the studies either from Western countries (HR 0.87, 95% CI 0.68-1.10) or Asian countries (HR 1.89, 95% CI 0.62-5.77). HRs were 0.86 (95% CI 0.38-1.94) and 1.57 (95% CI 0.73-3.39) for the studies using univariate analysis and multivariate analysis, respectively. HR from the studies that examined DNA level was significantly different (HR 2.05, 95% CI 1.22-3.46); while that about RNA level or protein level was not significantly different.Conclusion:
c-Myc was not associated with CRC prognosis in this meta-analysis. However, the conclusion is preliminary and should be examined in future studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article