The histone deacetylase inhibitor panobinostat exerts anticancer effects on esophageal squamous cell carcinoma cells by inducing cell cycle arrest.

Cheng, Yin-Wei; Liao, Lian-Di; Yang, Qian; Chen, Yang; Nie, Ping-Juan; Zhang, Xiao-Jun; Xie, Jian-Jun; Shan, Bao-En; Zhao, Lian-Mei; Xu, Li-Yan; Li, En-Min

Cheng, Yin-Wei; Liao, Lian-Di; Yang, Qian; Chen, Yang; Nie, Ping-Juan; Zhang, Xiao-Jun; Xie, Jian-Jun; Shan, Bao-En; Zhao, Lian-Mei; Xu, Li-Yan; Li, En-Min.

Afiliação

Cheng YW; The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, China.
Liao LD; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong, China.
Yang Q; The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, China.
Chen Y; Institute of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong, China.
Nie PJ; The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, China.
Zhang XJ; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong, China.
Xie JJ; The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, China.
Shan BE; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong, China.
Zhao LM; The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, China.
Xu LY; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong, China.
Li EM; The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, China.

Cell Biochem Funct ; 36(8): 398-407, 2018 Dec.

Article em En | MEDLINE | ID: mdl-30484863

Assuntos

Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Inibidores de Histona Desacetilases/farmacologia; Panobinostat/farmacologia; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Ciclina D1/genética; Ciclina D1/metabolismo; Inibidor de Quinase Dependente de Ciclina p21/genética; Inibidor de Quinase Dependente de Ciclina p21/metabolismo; Regulação para Baixo/efeitos dos fármacos; Neoplasias Esofágicas/metabolismo; Neoplasias Esofágicas/patologia; Carcinoma de Células Escamosas do Esôfago/metabolismo; Carcinoma de Células Escamosas do Esôfago/patologia; Humanos; Ácidos Hidroxâmicos/farmacologia; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Regulação para Cima/efeitos dos fármacos

Palavras-chave

HDAC inhibitors (HDACIs); TP53; cell cycle; esophageal squamous cell carcinoma (ESCC); panobinostat (LBH589)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Pontos de Checagem do Ciclo Celular / Panobinostat Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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