O-GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5.

Wu, Nan; Jiang, Mingzuo; Han, Yuying; Liu, Haiming; Chu, Yi; Liu, Hao; Cao, Jiayi; Hou, Qiuqiu; Zhao, Yu; Xu, Bing; Xie, Xin

Wu, Nan; Jiang, Mingzuo; Han, Yuying; Liu, Haiming; Chu, Yi; Liu, Hao; Cao, Jiayi; Hou, Qiuqiu; Zhao, Yu; Xu, Bing; Xie, Xin.

Afiliação

Wu N; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
Jiang M; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, China.
Han Y; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
Liu H; College of Computer Science and Technology, Jilin University, Changchun, Jilin, China.
Chu Y; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, China.
Liu H; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, China.
Cao J; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
Hou Q; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
Zhao Y; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
Xu B; Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiao tong University, Xi'an, Shaanxi, China.
Xie X; Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.

J Cell Mol Med ; 23(2): 1354-1362, 2019 02.

Article em En | MEDLINE | ID: mdl-30484950

Assuntos

Biomarcadores Tumorais/metabolismo; Neoplasias Colorretais/patologia; RNA Helicases DEAD-box/química; RNA Helicases DEAD-box/metabolismo; Processamento de Proteína Pós-Traducional; Proteínas Proto-Oncogênicas c-akt/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Animais; Apoptose; Biomarcadores Tumorais/genética; Movimento Celular; Proliferação de Células; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; RNA Helicases DEAD-box/genética; Progressão da Doença; Regulação Neoplásica da Expressão Gênica; Glicosilação; Humanos; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; N-Acetilglucosaminiltransferases/metabolismo; Estabilidade Proteica; Proteínas Proto-Oncogênicas c-akt/genética; Serina-Treonina Quinases TOR/genética; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

AKT; Colorectal cancer; DDX5; O-GlcNAcylation; mTOR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Processamento de Proteína Pós-Traducional / Proteínas Proto-Oncogênicas c-akt / RNA Helicases DEAD-box / Serina-Treonina Quinases TOR Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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