Inhibitory Effects of 2N1HIA (2-(3-(2-Fluoro-4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazinyl)-<i>N</i>-1H-Indol-5-Ylacetamide) on Osteoclast Differentiation via Suppressing Cathepsin K Expression.

Ahn, Sun-Hee; Chen, Zhihao; Lee, Jinkyung; Lee, Seok-Woo; Min, Sang Hyun; Kim, Nam Doo; Lee, Tae-Hoon

Inhibitory Effects of 2N1HIA (2-(3-(2-Fluoro-4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazinyl)-N-1H-Indol-5-Ylacetamide) on Osteoclast Differentiation via Suppressing Cathepsin K Expression.

Ahn, Sun-Hee; Chen, Zhihao; Lee, Jinkyung; Lee, Seok-Woo; Min, Sang Hyun; Kim, Nam Doo; Lee, Tae-Hoon.

Afiliação

Ahn SH; Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea. sun3193@hotmail.com.
Chen Z; Department of Molecular Medicine (BK21plus), Chonnam National University Graduate School, Gwangju 61186, Korea. chinaczhihao@gmail.com.
Lee J; Department of Molecular Medicine (BK21plus), Chonnam National University Graduate School, Gwangju 61186, Korea. wlsrud1945@naver.com.
Lee SW; Department of Dental Education and Periodontology, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea. swlee@jnu.ac.kr.
Min SH; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Dong-gu, Daegu 41061, Korea. shmin03@dgmif.re.kr.
Kim ND; NDBio Therapeutics Inc., S24 Floor, Songdogwahak-ro 32, Yeonsu-gu, Incheon 21984, Korea. namdoo@ndbio.co.kr.
Lee TH; Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea. thlee83@jnu.ac.kr.

Molecules ; 23(12)2018 Nov 29.

Article em En | MEDLINE | ID: mdl-30501117

Assuntos

Acetamidas/farmacologia; Catepsina K/metabolismo; Diferenciação Celular/efeitos dos fármacos; Osteoclastos/citologia; Osteoclastos/enzimologia; Actinas/metabolismo; Animais; Reabsorção Óssea/genética; Reabsorção Óssea/patologia; Antígeno CD47/metabolismo; Bovinos; Regulação da Expressão Gênica/efeitos dos fármacos; Masculino; Camundongos Endogâmicos C57BL; Osteoclastos/efeitos dos fármacos; Osteogênese/efeitos dos fármacos; Ligante RANK/farmacologia

Palavras-chave

bone resorption; cathepsin K; osteoclast; osteoporosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoclastos / Diferenciação Celular / Catepsina K / Acetamidas Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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