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Affective response to physical activity as an intermediate phenotype.
Lee, Harold H; Emerson, Jessica A; Bohlen, Lauren Connell; Williams, David M.
Afiliação
  • Lee HH; Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, USA. Electronic address: harold_lee@brown.edu.
  • Emerson JA; Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, USA.
  • Bohlen LC; Department of Kinesiology, University of Rhode Island, Kingston, RI, USA.
  • Williams DM; Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, USA.
Soc Sci Med ; 271: 112038, 2021 02.
Article em En | MEDLINE | ID: mdl-30502097
ABSTRACT
Over the past seventy years, biomedical and epidemiological research has shown that regular physical activity (PA) is critical for physical and mental health. Despite this knowledge, physical inactivity is the fourth leading risk factor for global mortality, accounting for 9% (5.3 million) of premature deaths annually. We suggest this mismatch between knowing about the risks of PA and engaging in regular PA can be reconciled by focusing less on expected health benefits of PA and more on how people feel during PA. Specifically, in this position paper, we argue that affective response (feeling good versus bad) to PA is an intermediate phenotype that can explain significant variance in PA behavior and is, in turn, a function of genetic variability. In making this argument, we first review empirical evidence showing that affective response to PA predicts future physical activity behavior. Second, we systematically review research on single nucleotide morphisms (SNPs) that are associated with affective response to PA. Investigating affective response to PA as an intermediate phenotype will allow future researchers to move beyond asking "What SNPs are associated with PA?", and begin asking "How do these SNPs influence PA?", thus ultimately optimizing the translation of knowledge gained from genomic data to intervention development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Comportamento Sedentário Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Comportamento Sedentário Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article