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LncRNA LCPAT1 is involved in DNA damage induced by CSE.
Gao, Sumeng; Lin, Hongyan; Yu, Wang; Zhang, Fangfang; Wang, Ruoyang; Yu, Herbert; Qian, Biyun.
Afiliação
  • Gao S; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Lin H; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Yu W; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Zhang F; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Wang R; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Yu H; Cancer Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, USA.
  • Qian B; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address: qianbiyun@sjtu.edu.cn.
Biochem Biophys Res Commun ; 508(2): 512-515, 2019 01 08.
Article em En | MEDLINE | ID: mdl-30509493
ABSTRACT
Cigarette smoking plays an important role in the process of lung cancer, during which DNA damage is proved to be involved. Non-coding RNAs are found to be involved in the DNA damage and repair processes induced by cigarette smoke. In the present study, we investigated the role of lncRNA LCPAT1 in DNA damage caused by CSE in Beas-2B cells. Our results indicate that LCPAT1, through RCC2 is involved in the CSE-induced DNA damage providing new insight into the lung carcinogenesis related to cigarette smoking.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fumaça / Dano ao DNA / RNA Longo não Codificante / Produtos do Tabaco Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fumaça / Dano ao DNA / RNA Longo não Codificante / Produtos do Tabaco Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article