Can Protein Expression Be Regulated by Modulation of tRNA Modification Profiles?
Biochemistry
; 58(5): 355-362, 2019 02 05.
Article
em En
| MEDLINE
| ID: mdl-30511849
ABSTRACT
tRNAs are the central adaptor molecules in translation. Their decoding properties are influenced by post-transcriptional modifications, particularly in the critical anticodon-stem-loop (ASL) region. Synonymous codon choice, also called codon usage bias, affects both translation efficiency and accuracy, and ASL modifications play key roles in both of these processes. In combination with a handful of historical examples, recent studies integrating ribosome profiling, proteomics, codon-usage analyses, and modification quantifications show that levels of tRNA modifications can change under stress, during development, or under specific metabolic conditions and can modulate the expression of specific genes. Deconvoluting the different responses (global or specific) to tRNA modification deficiencies can be difficult because of pleiotropic effects, but, as more cases emerge, it does seem that tRNA modification changes could add another layer of regulation in the transfer of information from DNA to protein.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribossomos
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Biossíntese de Proteínas
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Anticódon
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Códon
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RNA de Transferência
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Processamento Pós-Transcricional do RNA
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article