Interaction of Arylidenechromanone/Flavanone Derivatives with Biological Macromolecules Studied as Human Serum Albumin Binding, Cytotoxic Effect, Biocompatibility Towards Red Blood Cells.

Adamus-Grabicka, Angelika A; Markowicz-Piasecka, Magdalena; Ponczek, Michal B; Kusz, Joachim; Malecka, Magdalena; Krajewska, Urszula; Budzisz, Elzbieta

Adamus-Grabicka, Angelika A; Markowicz-Piasecka, Magdalena; Ponczek, Michal B; Kusz, Joachim; Malecka, Magdalena; Krajewska, Urszula; Budzisz, Elzbieta.

Afiliação

Adamus-Grabicka AA; Department of Cosmetic Raw Materials Chemistry, Faculty of Pharmacy, Medical University of Lodz, ulMuszynskiego 1, 90-151 Lodz, Poland. magdalena.markowicz@umed.lodz.pl.
Markowicz-Piasecka M; Laboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Muszynskiego1, 90-151 Lodz, Poland. michal.ponczek@biol.uni.lodz.pl.
Ponczek MB; Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland. joachim.kusz@us.edu.pl.
Kusz J; Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland. magdalena.malecka@chemia.uni.lodz.pl.
Malecka M; Department of Physical Chemistry, Theoretical and Structural Chemistry Group, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-236 Lodz, Poland. urszula.krajewska@umed.lodz.pl.
Krajewska U; Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. urszula.krajewska@umed.lodz.pl.
Budzisz E; Department of Cosmetic Raw Materials Chemistry, Faculty of Pharmacy, Medical University of Lodz, ulMuszynskiego 1, 90-151 Lodz, Poland. elzbieta.budzisz@umed.lodz.pl.

Molecules ; 23(12)2018 Dec 01.

Article em En | MEDLINE | ID: mdl-30513785

Assuntos

Eritrócitos/efeitos dos fármacos; Flavanonas/química; Flavanonas/farmacologia; Substâncias Macromoleculares/química; Albumina Sérica Humana/química; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Cristalografia por Raios X; Hemólise/efeitos dos fármacos; Humanos; Ligação de Hidrogênio; Substâncias Macromoleculares/síntese química; Substâncias Macromoleculares/metabolismo; Modelos Moleculares; Simulação de Acoplamento Molecular; Simulação de Dinâmica Molecular; Estrutura Molecular; Ligação Proteica; Albumina Sérica Humana/metabolismo; Relação Estrutura-Atividade

Palavras-chave

benzoflavanone/chromanone derivatives; crystal structure; cytotoxic effect; erythrotoxicity; synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavanonas / Substâncias Macromoleculares / Eritrócitos / Albumina Sérica Humana Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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