Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307.
J Antimicrob Chemother
; 74(3): 577-581, 2019 03 01.
Article
em En
| MEDLINE
| ID: mdl-30517666
ABSTRACT
OBJECTIVES:
Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes.METHODS:
We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced).RESULTS:
We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants.CONCLUSIONS:
Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Beta-Lactamases
/
Infecções por Klebsiella
/
Farmacorresistência Bacteriana
/
Enterobacteriáceas Resistentes a Carbapenêmicos
/
Genótipo
/
Klebsiella pneumoniae
Tipo de estudo:
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article