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Cervical cancer cell lines are sensitive to sub-erythemal UV exposure.
Gu, Wenyi; Sun, Surong; Kahn, Andrew; Dacus, Dalton; Wendel, Sebastian O; McMillan, Nigel; Wallace, Nicholas A.
Afiliação
  • Gu W; School of Medical Sciences, Griffith University, Gold Coast Campus, Australia.
  • Sun S; School of Medical Sciences, Griffith University, Gold Coast Campus, Australia; Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China.
  • Kahn A; Division of Biology, Kansas State University, Manhattan, KS, United States of America.
  • Dacus D; Division of Biology, Kansas State University, Manhattan, KS, United States of America.
  • Wendel SO; Division of Biology, Kansas State University, Manhattan, KS, United States of America.
  • McMillan N; School of Medical Sciences, Griffith University, Gold Coast Campus, Australia. Electronic address: n.mcmillan@griffith.edu.au.
  • Wallace NA; Division of Biology, Kansas State University, Manhattan, KS, United States of America. Electronic address: nwallac@ksu.edu.
Gene ; 688: 44-53, 2019 Mar 10.
Article em En | MEDLINE | ID: mdl-30517878
High risk human papillomavirus (HPV) infections are the causative agent in virtually every cervical cancer as well as a host of other anogenital and oropharyngeal malignancies. These viruses must activate DNA repair pathways to facilitate their replication, while avoiding the cell cycle arrest and apoptosis that can accompany DNA damage. HPV oncoproteins facilitate each of these goals, but also reduce genome stability. Our data dissect the cytotoxic and cytoprotective characteristics of HPV oncogenes in cervical cancer cells. These data show that while the transformation of keratinocytes by HPV oncogene leaves these cells more sensitive to UV, the oncogenes also protect against UV-induced apoptosis. Cisplatin and UV resistant cervical cancer cell lines were generated and probed for their sensitivity to genotoxic agents. Cervical cancer cells can acquire resistance to one DNA crosslinking agent (UV or cisplatin) without gaining broad tolerance of crosslinked DNA. Further, cisplatin resistance may or may not result in sensitivity to PARP1 inhibition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Raios Ultravioleta / Neoplasias do Colo do Útero / Eritema Tipo de estudo: Diagnostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Raios Ultravioleta / Neoplasias do Colo do Útero / Eritema Tipo de estudo: Diagnostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article