Postmortem protein stability investigations of the human hepatic drug-metabolizing cytochrome P450 enzymes CYP1A2 and CYP3A4 using mass spectrometry.

Hansen, Jakob; Palmfeldt, Johan; Pedersen, Kata Wolff; Funder, Anette Daa; Frost, Lise; Hasselstrøm, Jørgen Bo; Jornil, Jakob Ross

Hansen, Jakob; Palmfeldt, Johan; Pedersen, Kata Wolff; Funder, Anette Daa; Frost, Lise; Hasselstrøm, Jørgen Bo; Jornil, Jakob Ross.

Afiliação

Hansen J; Department of Forensic Medicine, Aarhus University, Denmark. Electronic address: jah@forens.au.dk.
Palmfeldt J; Research Unit for Molecular Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Denmark.
Pedersen KW; Department of Forensic Medicine, Aarhus University, Denmark.
Funder AD; Department of Forensic Medicine, Aarhus University, Denmark.
Frost L; Department of Forensic Medicine, Aarhus University, Denmark.
Hasselstrøm JB; Department of Forensic Medicine, Aarhus University, Denmark.
Jornil JR; Department of Forensic Medicine, Aarhus University, Denmark.

J Proteomics ; 194: 125-131, 2019 03 01.

Article em En | MEDLINE | ID: mdl-30529742

Assuntos

Citocromo P-450 CYP1A2/metabolismo; Citocromo P-450 CYP3A/metabolismo; Microssomos Hepáticos/enzimologia; Preservação Biológica; Estabilidade Enzimática; Feminino; Humanos; Masculino; Espectrometria de Massas; Mudanças Depois da Morte; Fatores de Tempo

Palavras-chave

Cytochrome P450; Drug metabolism; Forensic toxicology; Mass spectrometry; Postmortem tissue; Protein quantification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preservação Biológica / Microssomos Hepáticos / Citocromo P-450 CYP1A2 / Citocromo P-450 CYP3A Limite: Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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