The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates <i>In Vitro</i> and <i>In Vivo</i> Activity against Candida auris.

Wiederhold, Nathan P; Lockhart, Shawn R; Najvar, Laura K; Berkow, Elizabeth L; Jaramillo, Rosie; Olivo, Marcos; Garvey, Edward P; Yates, Christopher M; Schotzinger, Robert J; Catano, Gabriel; Patterson, Thomas F

The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris.

Wiederhold, Nathan P; Lockhart, Shawn R; Najvar, Laura K; Berkow, Elizabeth L; Jaramillo, Rosie; Olivo, Marcos; Garvey, Edward P; Yates, Christopher M; Schotzinger, Robert J; Catano, Gabriel; Patterson, Thomas F.

Afiliação

Wiederhold NP; University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA wiederholdn@uthscsa.edu.
Lockhart SR; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Najvar LK; University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Berkow EL; South Texas Veterans Health Care System, San Antonio, Texas, USA.
Jaramillo R; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Olivo M; University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Garvey EP; South Texas Veterans Health Care System, San Antonio, Texas, USA.
Yates CM; University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Schotzinger RJ; South Texas Veterans Health Care System, San Antonio, Texas, USA.
Catano G; Viamet Pharmaceuticals Inc., Durham, North Carolina, USA.
Patterson TF; Viamet Pharmaceuticals Inc., Durham, North Carolina, USA.

Antimicrob Agents Chemother ; 63(3)2019 03.

Article em En | MEDLINE | ID: mdl-30530603

Assuntos

Inibidores de 14-alfa Desmetilase/uso terapêutico; Antifúngicos/uso terapêutico; Candida/efeitos dos fármacos; Candidíase Invasiva/tratamento farmacológico; Piridinas/uso terapêutico; Tetrazóis/uso terapêutico; Animais; Candidíase Invasiva/microbiologia; Caspofungina/uso terapêutico; Modelos Animais de Doenças; Fluconazol/uso terapêutico; Humanos; Camundongos; Testes de Sensibilidade Microbiana; Esterol 14-Desmetilase/metabolismo

Palavras-chave

Candida auris; VT-1598; in vitro susceptibility; invasive candidiasis; murine model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Tetrazóis / Candida / Candidíase Invasiva / Inibidores de 14-alfa Desmetilase / Antifúngicos Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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