Molecular and Functional Interaction of the Myokine Irisin with Physical Exercise and Alzheimer's Disease.
Molecules
; 23(12)2018 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-30544500
ABSTRACT
Irisin, a skeletal muscle-secreted myokine, produced in response to physical exercise, has protective functions in both the central and the peripheral nervous systems, including the regulation of brain-derived neurotrophic factors. In particular, irisin is capable of protecting hippocampus. Since this area is the region of the brain that is most susceptible to Alzheimer's disease (AD), such beneficial effect may inhibit or delay the emergence of neurodegenerative diseases, including AD. Also, the factors engaged in irisin formation appear to suppress Aß aggregation, which is the pathological hallmark of AD. This review is based on the hypothesis that irisin produced by physical exercise helps to control AD progression. Herein, we describe the physiology of irisin and its potential role in delaying or preventing AD progression in human.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
/
Fibronectinas
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article