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Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms.
Park, Heuijoon; Lad, Sonali; Boland, Kelsey; Johnson, Kelly; Readio, Nyssa; Jin, Guangchun; Asfaha, Samuel; Patterson, Kelly S; Singh, Ashok; Yang, Xiangdong; Londono, Douglas; Singh, Anupama; Trempus, Carol; Gordon, Derek; Wang, Timothy C; Morris, Rebecca J.
Afiliação
  • Park H; Department of Pathology and Cell Biology, Columbia University, New York, 10032, NY, USA.
  • Lad S; Department of Dermatology, Columbia University, New York, 10032, NY, USA.
  • Boland K; Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, 10032, NY, USA.
  • Johnson K; The Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
  • Readio N; The Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
  • Jin G; The Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
  • Asfaha S; The Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
  • Patterson KS; The Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
  • Singh A; Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, 10032, NY, USA.
  • Yang X; Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, 10032, NY, USA.
  • Londono D; Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, 10032, NY, USA.
  • Singh A; The Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
  • Trempus C; Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, 10032, NY, USA.
  • Gordon D; Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, 08854-8082, NJ, USA.
  • Wang TC; The Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
  • Morris RJ; Matrix Biology Group, Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, 27709, NC, USA.
Nat Commun ; 9(1): 5293, 2018 12 13.
Article em En | MEDLINE | ID: mdl-30546048
ABSTRACT
We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Lineage-depleted BMCs migrated towards High Mobility Group Box 1 (HMGB1) protein and epidermal KCs in ex vivo invasion assays. Naive female mice receiving BMTs from DMBA-treated donors developed benign and malignant lesions after TPA promotion alone. We conclude that BMDECs contribute to the development of papillomas and dysplasia, demonstrating a systemic contribution to these lesions. Furthermore, carcinogen-exposed BMCs can initiate benign and malignant lesions upon tumor promotion. Ultimately, these findings may suggest targets for treatment of non-melanoma skin cancers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Células da Medula Óssea / Transformação Celular Neoplásica / Células Epiteliais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Células da Medula Óssea / Transformação Celular Neoplásica / Células Epiteliais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article