Angiotensin I-converting enzyme in human urine.
Clin Chim Acta
; 89(3): 375-9, 1978 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-30552
ABSTRACT
It was demonstrated that angiotensin I-converting enzyme was excreted in human urine. The mean activity of the enzyme in normal urine was found to be 0.38 +/- 0.04 (S.E.M.) units/day (n = 18) and the enzymic activity correlated well with the concentration of the excreted sodium (r = 0.76, p less than 0.005). Urinary angiotensin I-converting enzyme was partially purified. Three different molecular weights of enzyme (greater than 400 000, 290 000 and 140 000) were demonstrated by Sephadex G-200 gel filtration. The enzymic properties of these three enzymes were identical with those of angiotensin I-converting enzyme from human lung with regard to inhibitory effects (bradykinin potentiator c and Arg-Pro-Pro), Cl- dependency, pH optimum and KM value.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptidil Dipeptidase A
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article