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N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines.
Zhou, Jian; Negi, Arvind; Mirallai, Styliana I; Warta, Rolf; Herold-Mende, Christel; Carty, Michael P; Ye, Xin-Shan; Murphy, Paul V.
Afiliação
  • Zhou J; School of Chemistry and Chemical Biology, University College Dublin, Dublin 4, D04 V1W8, Ireland.
  • Negi A; School of Chemistry, National University of Ireland Galway, University Road, Galway H91 TK33, Ireland.
  • Mirallai SI; School of Chemistry, National University of Ireland Galway, University Road, Galway H91 TK33, Ireland.
  • Warta R; Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
  • Herold-Mende C; Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
  • Carty MP; School of Natural Sciences, Biochemistry and Centre for Chromosome Biology, National University of Ireland Galway, University Road, H91 TK33 Galway, Ireland.
  • Ye XS; State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China.
  • Murphy PV; School of Chemistry, National University of Ireland Galway, University Road, Galway H91 TK33, Ireland. Electronic address: paul.v.murphy@nuigalway.ie.
Bioorg Chem ; 84: 418-433, 2019 03.
Article em En | MEDLINE | ID: mdl-30554081
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcoois Açúcares / Inibidores Enzimáticos / Alfa-L-Fucosidase Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcoois Açúcares / Inibidores Enzimáticos / Alfa-L-Fucosidase Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article