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Impaired Transplacental Transfer of Respiratory Syncytial Virus-neutralizing Antibodies in Human Immunodeficiency Virus-infected Versus -uninfected Pregnant Women.
Jallow, Sabelle; Agosti, Yasmeen; Kgagudi, Prudence; Vandecar, Megan; Cutland, Clare L; Simões, Eric A F; Nunes, Marta C; Suchard, Melinda S; Madhi, Shabir A.
Afiliação
  • Jallow S; Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa.
  • Agosti Y; Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases Research, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
  • Kgagudi P; Centre for Vaccines and Immunology, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
  • Vandecar M; Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa.
  • Cutland CL; Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases Research, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
  • Simões EAF; Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa.
  • Nunes MC; Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases Research, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
  • Suchard MS; Centre for Vaccines and Immunology, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
  • Madhi SA; Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa.
Clin Infect Dis ; 69(1): 151-154, 2019 06 18.
Article em En | MEDLINE | ID: mdl-30561563
ABSTRACT
Human immunodeficiency virus (HIV)-exposed, uninfected infants have higher risks of respiratory syncytial virus-associated hospitalization than HIV-unexposed infants. Despite similar neutralizing antibody titers between HIV-infected and -uninfected women, maternal HIV infection and hypergammaglobulinemia were independently associated with lower titers in newborns. Maternal hypergammaglobulinemia was associated with lower cord-to-maternal antibody ratio.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Vírus Sincicial Respiratório Humano / Anticorpos Neutralizantes / Imunidade Materno-Adquirida / Anticorpos Antivirais Limite: Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Vírus Sincicial Respiratório Humano / Anticorpos Neutralizantes / Imunidade Materno-Adquirida / Anticorpos Antivirais Limite: Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article