An Optimized Method for the Proteomic Analysis of Low Volumes of Cell Culture Media and the Secretome: The Application and the Demonstration of Altered Protein Expression in iPSC-Derived Neuronal Cell Lines from Parkinson's Disease Patients.

Baud, Anna; Little, Daniel; Wen, Teo Qi; Heywood, Wendy E; Gissen, Paul; Mills, Kevin

Baud, Anna; Little, Daniel; Wen, Teo Qi; Heywood, Wendy E; Gissen, Paul; Mills, Kevin.

Afiliação

Baud A; Centre for Translational Omics , UCL Great Ormond Street Institute of Child Health , London , WC1N 1EH , U.K.
Little D; MRC Laboratory for Molecular Cell Biology , University College London , London , WC1E 6BT , U.K.
Wen TQ; Centre for Translational Omics , UCL Great Ormond Street Institute of Child Health , London , WC1N 1EH , U.K.
Heywood WE; Centre for Translational Omics , UCL Great Ormond Street Institute of Child Health , London , WC1N 1EH , U.K.
Gissen P; MRC Laboratory for Molecular Cell Biology , University College London , London , WC1E 6BT , U.K.
Mills K; Centre for Translational Omics , UCL Great Ormond Street Institute of Child Health , London , WC1N 1EH , U.K.

J Proteome Res ; 18(3): 1198-1207, 2019 03 01.

Article em En | MEDLINE | ID: mdl-30562036

Assuntos

Diferenciação Celular/genética; Meios de Cultura/metabolismo; Doença de Parkinson/genética; Proteômica; Linhagem Celular; Regulação da Expressão Gênica/genética; Humanos; Células-Tronco Pluripotentes Induzidas/metabolismo; Células-Tronco Mesenquimais/metabolismo; Neurônios/metabolismo; Doença de Parkinson/patologia

Palavras-chave

Parkinson's disease; induced pluripotent stem cells; mass spectrometry; proteomics; secretome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Diferenciação Celular / Meios de Cultura / Proteômica Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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