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The effect of screening-to-labor interval on the sensitivity of late-pregnancy culture in the prediction of group B streptococcus colonization at labor: A prospective multicenter cohort study.
Virranniemi, Minna; Raudaskoski, Tytti; Haapsamo, Mervi; Kauppila, Jaana; Renko, Marjo; Peltola, Joanna; Risteli, Leila; Laatio, Liisa.
Afiliação
  • Virranniemi M; PEDEGO Research Center, University of Oulu and Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
  • Raudaskoski T; PEDEGO Research Center, University of Oulu and Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
  • Haapsamo M; Department of Obstetrics & Gynecology, Rovaniemi Central Hospital, Rovaniemi, Finland.
  • Kauppila J; Department of Clinical Microbiology, Northern Finland Laboratory Center, Oulu, Finland.
  • Renko M; PEDEGO Research Center, University of Oulu and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
  • Peltola J; Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland.
  • Risteli L; Northern Finland Laboratory Center, Rovaniemi, Finland.
  • Laatio L; Department of Clinical Chemistry, Northern Finland Laboratory Center, Oulu, Finland.
Acta Obstet Gynecol Scand ; 98(4): 494-499, 2019 04.
Article em En | MEDLINE | ID: mdl-30578547
INTRODUCTION: The aim of this study was to evaluate the effect of increasing screening-to-labor interval on the performance of group B streptococcus (GBS) screening by late-pregnancy enriched culture compared with intrapartum real-time polymerase chain reaction (RT-PCR). MATERIAL AND METHODS: Group B streptococcus colonization was determined in 2624 women with singleton pregnancies by culture at 35-37 weeks of gestation and at the beginning of labor by culture and RT-PCR from recto-vaginal swab samples. RESULTS: Group B streptococcus colonization rates were 29.0% in late-pregnancy culture, 29.7% in intrapartum culture and 28.2% in intrapartum PCR. Intrapartum culture was used as a reference, the late-pregnancy culture had an overall sensitivity of 89.2% (95% CI 88.0%-90.4%) and specificity of 96.5% (95% CI 95.8%-97.2%), and intrapartum PCR had sensitivity of 91.5% (95% CI 90.4%-92.6%) and specificity of 98.5% (95% CI 98.0%-99.0%). However, up to 4 weeks after screening, the sensitivity of late-pregnancy culture was equivalent to or higher than that of RT-PCR. The RT-PCR was invalid in 0.9% of the women. Between late-pregnancy screening and labor, GBS colonization changed from negative to positive in 3.2% and from positive to negative in 2.5% of the women. CONCLUSIONS: The late-pregnancy enriched culture and intrapartum RT-PCR have comparable sensitivities in the detection of GBS when culture screening is conducted no more than 4 weeks before labor. Late-pregnancy culture sampling should be postponed to at least 37 weeks of gestation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Terceiro Trimestre da Gravidez / Infecções Estreptocócicas / Streptococcus agalactiae Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Terceiro Trimestre da Gravidez / Infecções Estreptocócicas / Streptococcus agalactiae Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article