Progress in diagnosis and surgical treatment of perihilar cholangiocarcinoma.
Gastroenterol Hepatol
; 42(4): 271-279, 2019 Apr.
Article
em En, Es
| MEDLINE
| ID: mdl-30583874
ABSTRACT
Cholangiocarcinomas are heterogeneous biliary tract tumors that cause devastating disease. Perihilar cholangiocarcinoma (PHC) is the most common type of biliary tract cancer and are associated with a high mortality. Diagnoses of PHC depend on the results of its clinical presentation, serum biomarkers and imaging techniques. Pre-operative managements including pre-operative biliary drainage (PBD) and portal vein embolization (PVE) could reduce mortality. The best chance of long-term survival and potential cure is surgical resection with negative surgical margin. Lymph node metastasis over N2 nodes precludes long-term survival. The benefit of concomitant vascular resection remains uncertain. Liver transplantation combined with neoadjuvant chemotherapy with radiotherapy is a promising option in highly selected patients with unresectable tumors. Herein, an overview is provided of developments in diagnosis, peri-operative management and surgical treatment among patients with PHCs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias dos Ductos Biliares
/
Tumor de Klatskin
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
/
Es
Ano de publicação:
2019
Tipo de documento:
Article