Bioactive megastigmane glucosides and monoterpenes from Lyonia ovalifolia.
J Asian Nat Prod Res
; 21(6): 559-572, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-30585522
ABSTRACT
Three new megastigmane glucosides (1-3) and two new monoterpenes (4-5), together with 14 related known compounds (6-19) were isolated from the twigs and leaves of Lyonia ovalifolia. The structures of the new compounds were determined by extensive MS, NMR, CD experiments and chemical methods. Compounds 2, 6, and 18 displayed potent antiviral activity against Coxsackie B3, with IC50 values between 6.4 and 14.6 µM. Additionally, compounds 6, 10, and 11 exhibited noteworthy anti-inflammatory activities, with inhibition rates ranging from 54.55% to 83.33% under the concentration of 10-5 M.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cicloexanonas
/
Ericaceae
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Norisoprenoides
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Glucosídeos
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article