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Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction.
Khera, Amit V; Chaffin, Mark; Zekavat, Seyedeh M; Collins, Ryan L; Roselli, Carolina; Natarajan, Pradeep; Lichtman, Judith H; D'Onofrio, Gail; Mattera, Jennifer; Dreyer, Rachel; Spertus, John A; Taylor, Kent D; Psaty, Bruce M; Rich, Stephen S; Post, Wendy; Gupta, Namrata; Gabriel, Stacey; Lander, Eric; Ida Chen, Yii-Der; Talkowski, Michael E; Rotter, Jerome I; Krumholz, Harlan M; Kathiresan, Sekar.
Afiliação
  • Khera AV; Center for Genomic Medicine (A.V.K., R.L.C., M.E.T., S.K.), Massachusetts General Hospital, Boston.
  • Chaffin M; Division of Cardiology (A.V.K., P.N., S.K.), Massachusetts General Hospital, Boston.
  • Zekavat SM; Cardio-vascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (A.V.K., M.C., S.M.Z., C.R., P.N., N.G., S.G., E.L., S.K.).
  • Collins RL; Department of Medicine (A.V.K., R.L.C., P.N., M.E.T., S.K.), Harvard Medical School, Boston, MA.
  • Roselli C; Cardio-vascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (A.V.K., M.C., S.M.Z., C.R., P.N., N.G., S.G., E.L., S.K.).
  • Natarajan P; Cardio-vascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (A.V.K., M.C., S.M.Z., C.R., P.N., N.G., S.G., E.L., S.K.).
  • Lichtman JH; Yale University School of Medicine, New Haven, CT (S.M.Z.).
  • D'Onofrio G; Center for Genomic Medicine (A.V.K., R.L.C., M.E.T., S.K.), Massachusetts General Hospital, Boston.
  • Mattera J; Department of Medicine (A.V.K., R.L.C., P.N., M.E.T., S.K.), Harvard Medical School, Boston, MA.
  • Dreyer R; Cardio-vascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (A.V.K., M.C., S.M.Z., C.R., P.N., N.G., S.G., E.L., S.K.).
  • Spertus JA; Division of Cardiology (A.V.K., P.N., S.K.), Massachusetts General Hospital, Boston.
  • Taylor KD; Cardio-vascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (A.V.K., M.C., S.M.Z., C.R., P.N., N.G., S.G., E.L., S.K.).
  • Psaty BM; Department of Medicine (A.V.K., R.L.C., P.N., M.E.T., S.K.), Harvard Medical School, Boston, MA.
  • Rich SS; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT (J.H.L.).
  • Post W; Department of Emergency Medicine, Yale University, New Haven, CT (G.D., R.D.).
  • Gupta N; Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, CT (J.M., H.M.K.).
  • Gabriel S; Department of Emergency Medicine, Yale University, New Haven, CT (G.D., R.D.).
  • Lander E; Department of Biomedical and Health Informatics, Saint Luke's Mid America Heart Institute, University of Missouri, Kansas City (J.A.S.).
  • Ida Chen YD; Institute for Translational Genomics and Population Sciences, LABioMed, Torrance, CA (K.D.T., Y.-D.I.C., J.I.R.).
  • Talkowski ME; Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, CA (K.D.T., Y.-D.I.C., J.I.R.).
  • Rotter JI; University of Washington and Kaiser Permanente, Seattle (B.M.P.).
  • Krumholz HM; Washington Health Research Institute, Seattle (B.M.P.).
  • Kathiresan S; Center for Public Health Genomics, University of Virginia School of Medicine, Richmond (S.S.R.).
Circulation ; 139(13): 1593-1602, 2019 03 26.
Article em En | MEDLINE | ID: mdl-30586733
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / Predisposição Genética para Doença / Herança Multifatorial / Hiperlipoproteinemia Tipo II / Infarto do Miocárdio Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / Predisposição Genética para Doença / Herança Multifatorial / Hiperlipoproteinemia Tipo II / Infarto do Miocárdio Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article