ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate K<sub>ATP</sub> channels.

Sikimic, Jelena; McMillen, Timothy S; Bleile, Cita; Dastvan, Frank; Quast, Ulrich; Krippeit-Drews, Peter; Drews, Gisela; Bryan, Joseph

ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate K_ATP channels.

Sikimic, Jelena; McMillen, Timothy S; Bleile, Cita; Dastvan, Frank; Quast, Ulrich; Krippeit-Drews, Peter; Drews, Gisela; Bryan, Joseph.

Afiliação

Sikimic J; From the Institute of Pharmacy, Department of Pharmacology, University of Tübingen, D-72076 Tübingen, Germany and.
McMillen TS; Pacific Northwest Diabetes Research Institute, Seattle, Washington 98122, and.
Bleile C; From the Institute of Pharmacy, Department of Pharmacology, University of Tübingen, D-72076 Tübingen, Germany and.
Dastvan F; Pacific Northwest Diabetes Research Institute, Seattle, Washington 98122, and.
Quast U; Department of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, D-72074 Tübingen, Germany.
Krippeit-Drews P; From the Institute of Pharmacy, Department of Pharmacology, University of Tübingen, D-72076 Tübingen, Germany and.
Drews G; From the Institute of Pharmacy, Department of Pharmacology, University of Tübingen, D-72076 Tübingen, Germany and.
Bryan J; Pacific Northwest Diabetes Research Institute, Seattle, Washington 98122, and jbryan1941@outlook.com.

J Biol Chem ; 294(10): 3707-3719, 2019 03 08.

Article em En | MEDLINE | ID: mdl-30587573

Assuntos

Trifosfato de Adenosina/metabolismo; Canais de Potássio Corretores do Fluxo de Internalização/metabolismo; Receptores de Sulfonilureias/química; Receptores de Sulfonilureias/metabolismo; Difosfato de Adenosina/metabolismo; Regulação Alostérica; Animais; Sítios de Ligação; Cricetinae; Guanosina Trifosfato/metabolismo; Células HEK293; Humanos; Hidrólise; Ativação do Canal Iônico; Modelos Moleculares; Mutação; Canais de Potássio Corretores do Fluxo de Internalização/química; Ligação Proteica; Conformação Proteica em alfa-Hélice

Palavras-chave

ABC transporter; ATP-binding cassette transporter subfamily C member 8 (ABCC8); ATP-sensitive potassium channel; KATP channel; KCNJ11 (Kir6.2); SUR1; allosteric regulation; congenital hyperinsulinism; diabetes; glibenclamide; hyperinsulinism; ion channel; metabolic sensor; neonatal diabetes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trifosfato de Adenosina / Canais de Potássio Corretores do Fluxo de Internalização / Receptores de Sulfonilureias Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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