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A DNA minimachine for selective and sensitive detection of DNA.

Lyalina, Tatiana A; Goncharova, Ekaterina A; Prokofeva, Nadezhda Y; Voroshilina, Ekaterina S; Kolpashchikov, Dmitry M.
Analyst ; 144(2): 416-420, 2019 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-30600819
Synthetic molecular machines have been explored to manipulate matter at the molecular level. Here, we designed a multifunctional DNA nano-construct, dubbed a 'DNA minimachine' (DMM), which (i) tightly binds complementary DNA; (ii) recognizes specific fragments with high selectivity and (iii) amplifies output signals. DMM1 detects lower concentrations of both single-stranded DNA and double-stranded DNA compared to a conventional probe. This study sets a direction towards the development of molecular machines for selective, sensitive and cost-efficient DNA analysis.