Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities.
J Nat Prod
; 82(1): 154-162, 2019 01 25.
Article
em En
| MEDLINE
| ID: mdl-30600998
ABSTRACT
Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1-6, together with five known compounds, 7-11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structural scaffolds, and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores Enzimáticos
/
Proteína de Translocação 1 do Linfoma de Tecido Linfoide Associado à Mucosa
/
Fungos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article