Metabolic profiling analysis upon acylcarnitines in tissues of hepatocellular carcinoma revealed the inhibited carnitine shuttle system caused by the downregulated carnitine palmitoyltransferase 2.

Lu, Xin; Zhang, Xiaohan; Zhang, Yongjian; Zhang, Kun; Zhan, Chao; Shi, Xiuyun; Li, Yiqun; Zhao, Jianxiang; Bai, Yunfan; Wang, Yu; Nie, Huan; Li, Yu

Lu, Xin; Zhang, Xiaohan; Zhang, Yongjian; Zhang, Kun; Zhan, Chao; Shi, Xiuyun; Li, Yiqun; Zhao, Jianxiang; Bai, Yunfan; Wang, Yu; Nie, Huan; Li, Yu.

Afiliação

Lu X; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Zhang X; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Zhang Y; The Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
Zhang K; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Zhan C; The Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
Shi X; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Li Y; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Zhao J; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Bai Y; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Wang Y; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Nie H; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Li Y; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.

Mol Carcinog ; 58(5): 749-759, 2019 05.

Article em En | MEDLINE | ID: mdl-30604893

Assuntos

Biomarcadores Tumorais/metabolismo; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Carnitina O-Palmitoiltransferase/metabolismo; Carnitina/análogos & derivados; Carnitina/metabolismo; Metaboloma; Apoptose; Carnitina O-Palmitoiltransferase/antagonistas & inibidores; Carnitina O-Palmitoiltransferase/genética; Estudos de Casos e Controles; Proliferação de Células; Seguimentos; Humanos; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Prognóstico; RNA Interferente Pequeno/genética; Células Tumorais Cultivadas

Palavras-chave

CPT2; liver cancer; metabolomics; ß-oxidation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina / Carnitina O-Palmitoiltransferase / Biomarcadores Tumorais / Carcinoma Hepatocelular / Metaboloma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google