Design and in Vivo Characterization of A<sub>1</sub> Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series.

Tosh, Dilip K; Rao, Harsha; Bitant, Amelia; Salmaso, Veronica; Mannes, Philip; Lieberman, David I; Vaughan, Kelli L; Mattison, Julie A; Rothwell, Amy C; Auchampach, John A; Ciancetta, Antonella; Liu, Naili; Cui, Zhenzhong; Gao, Zhan-Guo; Reitman, Marc L; Gavrilova, Oksana; Jacobson, Kenneth A

Design and in Vivo Characterization of A₁ Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series.

Tosh, Dilip K; Rao, Harsha; Bitant, Amelia; Salmaso, Veronica; Mannes, Philip; Lieberman, David I; Vaughan, Kelli L; Mattison, Julie A; Rothwell, Amy C; Auchampach, John A; Ciancetta, Antonella; Liu, Naili; Cui, Zhenzhong; Gao, Zhan-Guo; Reitman, Marc L; Gavrilova, Oksana; Jacobson, Kenneth A.

Afiliação

Bitant A; Department of Pharmacology , Medical College of Wisconsin , 8701 Watertown Plank Road , Milwaukee , Wisconsin 53226 , United States.
Vaughan KL; SoBran BioSciences , SoBran, Inc. , 4000 Blackburn Lane , Burtonsville , Maryland 20866 , United States.
Mattison JA; Translational Gerontology Branch , National Institute on Aging Intramural Research Program , 16701 Elmer School Road, Building 103 , Dickerson , Maryland 20842 , United States.
Rothwell AC; Translational Gerontology Branch , National Institute on Aging Intramural Research Program , 16701 Elmer School Road, Building 103 , Dickerson , Maryland 20842 , United States.
Auchampach JA; Department of Pharmacology , Medical College of Wisconsin , 8701 Watertown Plank Road , Milwaukee , Wisconsin 53226 , United States.
Ciancetta A; Department of Pharmacology , Medical College of Wisconsin , 8701 Watertown Plank Road , Milwaukee , Wisconsin 53226 , United States.
Liu N; School of Pharmacy , Queen's University Belfast , 96 Lisburn Road , Belfast BT9 7BL , U.K.

J Med Chem ; 62(3): 1502-1522, 2019 02 14.

Article em En | MEDLINE | ID: mdl-30605331

Assuntos

Agonistas do Receptor A1 de Adenosina/farmacologia; Adenosina/análogos & derivados; Adenosina/farmacologia; Compostos Bicíclicos com Pontes/farmacologia; Adenosina/síntese química; Agonistas do Receptor A1 de Adenosina/síntese química; Agonistas do Receptor A1 de Adenosina/farmacocinética; Animais; Compostos Bicíclicos com Pontes/síntese química; Compostos Bicíclicos com Pontes/farmacocinética; Células CHO; Cricetulus; Desenho de Fármacos; Células HEK293; Humanos; Macaca fascicularis; Masculino; Camundongos Endogâmicos C57BL; Simulação de Acoplamento Molecular; Estrutura Molecular; Receptor A1 de Adenosina/metabolismo; Relação Estrutura-Atividade

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Bicíclicos com Pontes / Adenosina / Agonistas do Receptor A1 de Adenosina Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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