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Neuroimaging and clinical trials with stem cells in amyotrophic lateral sclerosis: present and future perspectives. / Neuroimagen y ensayos clínicos con células madre en la esclerosis lateral amiotrófica: perspectivas de presente y futuro.
García Santos, J M; García Martínez-Lozano, M; Vázquez Olmos, C; Blanquer, M.
Afiliação
  • García Santos JM; Servicio de Radiología, Hospital General Universitario Morales Meseguer, Murcia, España; Facultad de Medicina, Universidad de Murcia, Murcia, España. Electronic address: josem.garcia11@carm.es.
  • García Martínez-Lozano M; Facultad de Medicina, Universidad de Murcia, Murcia, España.
  • Vázquez Olmos C; Servicio de Radiología, Hospital General Universitario Morales Meseguer, Murcia, España.
  • Blanquer M; Unidad de Trasplante Hematopoyético y Terapia Celular, Servicio de Hematología, Hospital Universitario Virgen de la Arrixaca, Instituto Murciano de Investigación Biomédica (IMIB), Campus Mare Nostrum, Universidad de Murcia, Murcia, España.
Radiologia (Engl Ed) ; 61(3): 183-190, 2019.
Article em En, Es | MEDLINE | ID: mdl-30606510
Amyotrophic lateral sclerosis is a rare neurodegenerative disease with a rapid fatal course. The absence of effective treatments has led to new lines of research, some of which are based on stem cells. Surgical injection into the spinal cord, the most common route of administration of stem cells, has proven safe in trials to test the safety of the procedure. Nevertheless, challenges remain, such as determining the best route of administration or the way of checking the survival of the cells and their interaction with the therapeutic target. To date, the mission of neuroimaging techniques has been to detect lesions and complications in the spine and spinal cord, but neuroimaging also has the potential to supplant histologic study in analyzing the relations between the implanted cells and the therapeutic target, and as biomarkers of the disease, by measuring morphological and functional changes after treatment. These developments would increase the role of radiologists in the clinical management of patients with amyotrophic lateral sclerosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco / Células-Tronco Neurais / Neuroimagem / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En / Es Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco / Células-Tronco Neurais / Neuroimagem / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En / Es Ano de publicação: 2019 Tipo de documento: Article