Your browser doesn't support javascript.
loading
Electromagnetic source imaging in presurgical workup of patients with epilepsy: A prospective study.
Duez, Lene; Tankisi, Hatice; Hansen, Peter Orm; Sidenius, Per; Sabers, Anne; Pinborg, Lars H; Fabricius, Martin; Rásonyi, György; Rubboli, Guido; Pedersen, Birthe; Leffers, Anne-Mette; Uldall, Peter; Jespersen, Bo; Brennum, Jannick; Henriksen, Otto Mølby; Fuglsang-Frederiksen, Anders; Beniczky, Sándor.
Afiliação
  • Duez L; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Tankisi H; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Hansen PO; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Sidenius P; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Sabers A; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Pinborg LH; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Fabricius M; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Rásonyi G; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Rubboli G; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Pedersen B; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Leffers AM; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Uldall P; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Jespersen B; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Brennum J; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Henriksen OM; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Fuglsang-Frederiksen A; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
  • Beniczky S; From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Phy
Neurology ; 92(6): e576-e586, 2019 02 05.
Article em En | MEDLINE | ID: mdl-30610090
ABSTRACT

OBJECTIVE:

To determine the diagnostic accuracy and clinical utility of electromagnetic source imaging (EMSI) in presurgical evaluation of patients with epilepsy.

METHODS:

We prospectively recorded magnetoencephalography (MEG) simultaneously with EEG and performed EMSI, comprising electric source imaging, magnetic source imaging, and analysis of combined MEG-EEG datasets, using 2 different software packages. As reference standard for irritative zone (IZ) and seizure onset zone (SOZ), we used intracranial recordings and for localization accuracy, outcome 1 year after operation.

RESULTS:

We included 141 consecutive patients. EMSI showed localized epileptiform discharges in 94 patients (67%). Most of the epileptiform discharge clusters (72%) were identified by both modalities, 15% only by EEG, and 14% only by MEG. Agreement was substantial between inverse solutions and moderate between software packages. EMSI provided new information that changed the management plan in 34% of the patients, and these changes were useful in 80%. Depending on the method, EMSI had a concordance of 53% to 89% with IZ and 35% to 73% with SOZ. Localization accuracy of EMSI was between 44% and 57%, which was not significantly different from MRI (49%-76%) and PET (54%-85%). Combined EMSI achieved significantly higher odds ratio compared to electric source imaging and magnetic source imaging.

CONCLUSION:

EMSI has accuracy similar to established imaging methods and provides clinically useful, new information in 34% of the patients. CLASSIFICATION OF EVIDENCE This study provides Class IV evidence that EMSI had a concordance of 53%-89% and 35%-73% (depending on analysis) for the localization of epileptic focus as compared with intracranial recordings-IZ and SOZ, respectively.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article