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TP53 and Prognosis in mCRPC Survival: Biology or Coincidence?
Rebello, Richard J; Oing, Christoph; Gillessen, Silke; Bristow, Robert G.
Afiliação
  • Rebello RJ; Translational Oncogenomics Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester Cancer Research Centre, Manchester, United Kingdom.
  • Oing C; Translational Oncogenomics Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester Cancer Research Centre, Manchester, United Kingdom.
  • Gillessen S; Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Eppendorf, Hamburg, Germany.
  • Bristow RG; Translational Oncogenomics Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester Cancer Research Centre, Manchester, United Kingdom.
Clin Cancer Res ; 25(6): 1699-1701, 2019 03 15.
Article em En | MEDLINE | ID: mdl-30610102
ABSTRACT
Cell-free circulating tumor DNA (ctDNA) or circulating tumor cell (CTC) assays are potentially powerful in the treatment of metastatic castration-resistant prostate cancer (mCRPC). A new study suggests that mutation of TP53 supersedes AR in predicting mCRPC survival. A role for TP53 mutation as a driver for mCRPC remains unexplored.See related article by De Laere et al., p. 1766.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Próstata Resistentes à Castração / Células Neoplásicas Circulantes Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Próstata Resistentes à Castração / Células Neoplásicas Circulantes Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article