Rhodium-Catalyzed Asymmetric Hydroamination of Allyl Amines.
J Am Chem Soc
; 141(2): 739-742, 2019 01 16.
Article
em En
| MEDLINE
| ID: mdl-30614700
ABSTRACT
A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ródio
/
Compostos Alílicos
/
Aminas
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article