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Rhodium-Catalyzed Asymmetric Hydroamination of Allyl Amines.
Vanable, Evan P; Kennemur, Jennifer L; Joyce, Leo A; Ruck, Rebecca T; Schultz, Danielle M; Hull, Kami L.
Afiliação
  • Vanable EP; Department of Chemistry , University of Illinois at Urbana-Champaign , 600 S. Mathews , Urbana , Illinois 61801 , United States.
  • Kennemur JL; Department of Chemistry , University of Illinois at Urbana-Champaign , 600 S. Mathews , Urbana , Illinois 61801 , United States.
  • Joyce LA; Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
  • Ruck RT; Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
  • Schultz DM; Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
  • Hull KL; Department of Chemistry , University of Illinois at Urbana-Champaign , 600 S. Mathews , Urbana , Illinois 61801 , United States.
J Am Chem Soc ; 141(2): 739-742, 2019 01 16.
Article em En | MEDLINE | ID: mdl-30614700
ABSTRACT
A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ródio / Compostos Alílicos / Aminas Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ródio / Compostos Alílicos / Aminas Idioma: En Ano de publicação: 2019 Tipo de documento: Article