[Clinical application of high mobility group box nuclear protein 1 subcomponent in the progression of liver cancer].
Zhonghua Gan Zang Bing Za Zhi
; 26(11): 869-872, 2018 Nov 20.
Article
em Zh
| MEDLINE
| ID: mdl-30616326
ABSTRACT
The biological functions of high-mobility group (HMG) proteins include regulation of DNA replication, transcription, recombination and repair. According to molecular weight, sequence alignment and DNA structural characteristics, HMG proteins are subdivided into three superfamilies (HMGA, HMGB and HMGN). Recently, HMGB family members (HMGB1, HMGB2, HMGB3, and HMGB4) found to interact with hepatitis B or C virus. Therefore, activation of relevant signaling molecules to regulate transcription of genes related to hepatocellular carcinoma as a mediator of inflammation promoting HCC progression has attracted considerable attentions. This article focuses on the clinical application of the expression of HMGB family members in the process of HCC progression.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transporte Proteico
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Proteína HMGB1
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Neoplasias Hepáticas
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Humans
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article