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Biologic modelling of periodontal disease progression.
Nagarajan, Radhakrishnan; Miller, Craig S; Dawson, Dolph; Ebersole, Jeffrey L.
Afiliação
  • Nagarajan R; Division of Biomedical Informatics, College of Medicine, University of Kentucky, Lexington, Kentucky.
  • Miller CS; Division of Oral Diagnosis, Oral Medicine and Oral Radiology, University of Kentucky, Lexington, Kentucky.
  • Dawson D; Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, Kentucky.
  • Ebersole JL; Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, Kentucky.
J Clin Periodontol ; 46(2): 160-169, 2019 02.
Article em En | MEDLINE | ID: mdl-30629741
ABSTRACT

AIM:

To investigate the synergistic role of biologic markers from saliva, serum and plaque in modelling periodontitis disease progression. MATERIAL AND

METHODS:

This longitudinal study evaluated characteristics of disease progression in 114 patients with generalized moderate to severe periodontitis. The primary outcome was detection of sites with progressing attachment loss sites over 6 months in patients who received scaling and root planing or oral hygiene only. The predictive potential of 27 biomarkers in serum, whole saliva and subgingival plaque was evaluated using three classification algorithms (Support Vector Machines; Naïve Bayes Classifier; and Linear Discriminant Analysis) within an ensemble predictive modelling framework.

RESULTS:

Disease progression occurred in 24.6% of subjects (28/114). Predictive modelling using Naïve Bayes Classifier identified progressors best with sensitivity of ~89%. The use of the three classification algorithms revealed the concerted role of salivary matrix metalloproteinase-8, serum biomarkers (serum amyloid P, matrix metalloproteinase 1, bactericidal permeability-increasing protein, isoprostane) along with levels of Porphryomonas gingivalis and Tannerella forsythia in plaque in predicting progressors.

CONCLUSIONS:

Synergistic utility of baseline bacterial and inflammatory biomarkers from saliva, serum and plaque predicted disease progression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Periodontite Crônica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Periodontite Crônica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article