Antifungal activity of selected Malassezia indolic compounds detected in culture.
Mycoses
; 62(7): 597-603, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-30636018
ABSTRACT
BACKGROUND:
Malassezia yeasts produce bioactive indolic substances when grown on L-tryptophan agar. A panel of these substances was tested against commensal and opportunistic fungi, the Minimum Inhibitory Concentration (MIC) was determined and the potential for in loco antifungal activity on the skin was assessed. MATERIALS ANDMETHODS:
Eight indoles were included (malassezin, pityriacitrin, indirubin, indolo[3,2-b]carbazole, 6-formylindolo[3,2-b]carbazole, tryptanthrin, 6-hydroxymethylindolo[3,2-b]carbazole and 6-methylindolo[3,2-b]carbazole) and were tested against 40 fungal strains [yeasts Malassezia spp.(N = 9); Cryptococcus spp.(N = 10); Candida spp.(N = 7); Yarrowia lipolytica(N = 1); Exophialla dermatitidis (N = 2); moulds Aspergillus spp.(N = 7); Fusarium spp.(N = 2); Rhizopus oryzae(N = 2)]. The concentration of 5/8 of the tested indoles on diseased skin was calculated from published data. Kruskal-Wallis and Mann-Whitney U tests were employed for group susceptibility evaluation in 33 strains.RESULTS:
The MIC range was 0.125-32 µg/mL, and the median log2 MIC was four. Indirubin was the most potent antifungal agent and differed significantly from the others. The highest median MIC was found for FICZ. Malassezia with Candida strains were more susceptible compared to Cryptococcus and Aspergillus, and this inhibitory activity was predicted to be valid also on human skin.CONCLUSIONS:
Malassezia yeasts produce indolic species that inhibit an array of clinically significant yeasts and moulds.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Meios de Cultura
/
Fungos
/
Indóis
/
Malassezia
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Antifúngicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article