Your browser doesn't support javascript.

Portal de Pesquisa da BVS

Informação e Conhecimento para a Saúde

Home > Pesquisa > ()
XML
Imprimir Exportar

Formato de exportação:

Exportar

Email
Adicionar mais destinatários
| |

A conserved filamentous assembly underlies the structure of the meiotic chromosome axis.

West, Alan Mv; Rosenberg, Scott C; Ur, Sarah N; Lehmer, Madison K; Ye, Qiaozhen; Hagemann, Götz; Caballero, Iracema; Usón, Isabel; MacQueen, Amy J; Herzog, Franz; Corbett, Kevin D.
Elife ; 82019 01 18.
Artigo em Inglês | MEDLINE | ID: mdl-30657449
The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged. Here, we show that 'axis core proteins' from budding yeast (Red1), mammals (SYCP2/SYCP3), and plants (ASY3/ASY4) are evolutionarily related and play equivalent roles in chromosome axis assembly. We first identify 'closure motifs' in each complex that recruit meiotic HORMADs, the master regulators of meiotic recombination. We next find that axis core proteins form homotetrameric (Red1) or heterotetrameric (SYCP2SYCP3 and ASY3ASY4) coiled-coil assemblies that further oligomerize into micron-length filaments. Thus, the meiotic chromosome axis core in fungi, mammals, and plants shares a common molecular architecture, and likely also plays conserved roles in meiotic chromosome axis assembly and recombination control.