Gemcitabine combined with docetaxel precisely regressed a recurrent leiomyosarcoma peritoneal metastasis in a patient-derived orthotopic xenograft (PDOX) model.
Biochem Biophys Res Commun
; 509(4): 1041-1046, 2019 02 19.
Article
em En
| MEDLINE
| ID: mdl-30660363
ABSTRACT
There are no effective treatments for leiomyosarcoma (LMS) spreading intraabdominally. The aim of this study was to develop precision chemotherapy for recurrent peritoneal LMS metastases in a patient-derived orthotopic xenograft (PDOX) model. The LMS PDOX models were established orthotopically on the dome of the bladder of nude mice. The LMS PDOX models were randomized into 6 groups when the tumor volume reached 80â¯mm3 G1 untreated control; G2 doxorubicin (DOX) (DOX i.p., 3â¯mg/kg, weekly, 3 weeks); G3 DOX combined with olaratumab (OLA) (DOX i.p., 3â¯mg/kg, weekly, 3 weeks; OLA i.p., 40â¯mg/kg, 3 times/week, 3 weeks); G4 gemcitabine (GEM) combined with docetaxel (DOC) (GEM i.p., 100⯠mg/kg, weekly, 3 weeks; DOC i.p., 20⯠mg/kg, weekly, 3 weeks); G5 pazopanib (PAZ) (PAZ p.o., 100⯠mg/kg, daily, 3 weeks); G6 palbociclib (PAL) (PAL p.o., 100⯠mg/kg, daily, 3 weeks). All mice were sacrificed on day 22. Body weight was assessed twice a week. Tumor volume was measured on day 0 and day 22. Although all regimens had a significant efficacy compared to the untreated group (Pâ¯<â¯0.001), only GEM combined with DOC regressed the tumor significantly (Pâ¯<â¯0.001), suggesting GEM combined with DOC has clinical potential for this LMS patient.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Peritoneais
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Desoxicitidina
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Docetaxel
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Leiomiossarcoma
Tipo de estudo:
Clinical_trials
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article