New citrinin derivatives from the deep-sea-derived fungus Cladosporium sp. SCSIO z015.
Nat Prod Res
; 34(9): 1219-1226, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-30663375
ABSTRACT
During the course of our search for novel bioactive compounds from marine fungi, four new citrinin derivatives, cladosporins A-D (1-4) were isolated from a culture broth of the deep-sea-derived fungus Cladosporium sp. SCSIO z015. Their complete structural assignments were elucidated by the extensive spectroscopic investigation. The absolute configurations of 1-3 were established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compounds 1-4 showed weak toxicity towards brine shrine naupalii with LC50 values of 72.0, 81.7, 49.9 and 81.4 µM, respectively. And 4 also showed significant antioxidant activity against É,α-diphenyl-picrylhydrazyl (DPPH) radicals with an IC50 value of 16.4 µM.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citrinina
/
Cladosporium
/
Antioxidantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article