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Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease.
Preische, Oliver; Schultz, Stephanie A; Apel, Anja; Kuhle, Jens; Kaeser, Stephan A; Barro, Christian; Gräber, Susanne; Kuder-Buletta, Elke; LaFougere, Christian; Laske, Christoph; Vöglein, Jonathan; Levin, Johannes; Masters, Colin L; Martins, Ralph; Schofield, Peter R; Rossor, Martin N; Graff-Radford, Neill R; Salloway, Stephen; Ghetti, Bernardino; Ringman, John M; Noble, James M; Chhatwal, Jasmeer; Goate, Alison M; Benzinger, Tammie L S; Morris, John C; Bateman, Randall J; Wang, Guoqiao; Fagan, Anne M; McDade, Eric M; Gordon, Brian A; Jucker, Mathias.
Afiliação
  • Preische O; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Schultz SA; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
  • Apel A; Department of Neurology, Department of Radiology, and Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
  • Kuhle J; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Kaeser SA; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
  • Barro C; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Gräber S; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Kuder-Buletta E; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
  • LaFougere C; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Laske C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Vöglein J; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Levin J; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Masters CL; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Martins R; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
  • Schofield PR; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Rossor MN; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Graff-Radford NR; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Salloway S; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Ghetti B; Neurodegeneration Division, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
  • Ringman JM; School of Medical Health and Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
  • Noble JM; Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Chhatwal J; Neuroscience Research Australia, Randwick, New South Wales, Australia.
  • Goate AM; School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
  • Benzinger TLS; Dementia Research Centre, Department of Neurodegeneration, Queen Square Institute of Neurology, University College London, London, UK.
  • Morris JC; Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL, USA.
  • Bateman RJ; Warren Alpert Medical School of Brown University, Providence, RI, USA.
  • Wang G; Indiana Alzheimer Disease Center and Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Fagan AM; Department of Neurology, Keck School of Medicine at USC, Los Angeles, CA, USA.
  • McDade EM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Gordon BA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Jucker M; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nat Med ; 25(2): 277-283, 2019 02.
Article em En | MEDLINE | ID: mdl-30664784
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Neurofilamentos / Progressão da Doença / Doença de Alzheimer / Degeneração Neural Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Neurofilamentos / Progressão da Doença / Doença de Alzheimer / Degeneração Neural Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article