Reduced FEV1/FVC and FEV1 in the Normal Range as a Physiological Variant.
Respir Care
; 64(5): 570-575, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-30670670
ABSTRACT
BACKGROUND:
Healthy individuals without respiratory symptoms can sometimes present with low FEV1/FVC. The objective of this study was to characterize and compare subjects without symptoms and with reduced FEV1/FVC but normal FEV1 with subjects with mild obstructive lung disease.METHODS:
Fifty healthy subjects with FEV1/FVC below the fifth percentile of reference values (normal variants) were compared with 52 subjects with asthma and 48 subjects with COPD who had similar FEV1/FVC.RESULTS:
Subjects without symptoms were more likely to be male, younger, and taller, and to have higher FVC%, FEV1%, mid expiratory flow, and terminal flow than subjects with obstructive disease. A receiver operating characteristic curve analysis determined that the best separation between the groups was provided by age < 55 y, height ≥ 167 cm, and FVC > 105%. A logistic regression analysis confirmed that male sex, age, FVC%, and FEF75 (Forced expiratory flow in 75% of forced vital capacity) were significant factors for discriminating subjects without symptoms from those with obstructive lung disease.CONCLUSIONS:
A reduced FEV1/FVC may be a normal finding in younger-to-middle age male subjects with an FVC% value above the mean predicted value, especially when terminal flow is within the normal range.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Doença Pulmonar Obstrutiva Crônica
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article