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Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity.
Hulpia, Fabian; Campagnaro, Gustavo Daniel; Scortichini, Mirko; Van Hecke, Kristof; Maes, Louis; de Koning, Harry P; Caljon, Guy; Van Calenbergh, Serge.
Afiliação
  • Hulpia F; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium.
  • Campagnaro GD; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, United Kingdom.
  • Scortichini M; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032, Camerino, Italy.
  • Van Hecke K; XStruct, Department of Chemistry, Ghent University, Krijgslaan 281 (S3), B-9000, Gent, Belgium.
  • Maes L; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Universiteitsplein 1 (S7), B-2610, Wilrijk, Belgium.
  • de Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, United Kingdom.
  • Caljon G; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Universiteitsplein 1 (S7), B-2610, Wilrijk, Belgium.
  • Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium. Electronic address: serge.vancalenbergh@ugent.be.
Eur J Med Chem ; 164: 689-705, 2019 Feb 15.
Article em En | MEDLINE | ID: mdl-30677668
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tubercidina / Kinetoplastida Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tubercidina / Kinetoplastida Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article