The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.

Guo, Feng-Xia; Wu, Qian; Li, Pan; Zheng, Lei; Ye, Shu; Dai, Xiao-Yan; Kang, Chun-Min; Lu, Jing-Bo; Xu, Bang-Ming; Xu, Yuan-Jun; Xiao, Lei; Lu, Zhi-Feng; Bai, Huan-Lan; Hu, Yan-Wei; Wang, Qian

Guo, Feng-Xia; Wu, Qian; Li, Pan; Zheng, Lei; Ye, Shu; Dai, Xiao-Yan; Kang, Chun-Min; Lu, Jing-Bo; Xu, Bang-Ming; Xu, Yuan-Jun; Xiao, Lei; Lu, Zhi-Feng; Bai, Huan-Lan; Hu, Yan-Wei; Wang, Qian.

Afiliação

Guo FX; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Wu Q; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Li P; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zheng L; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ye S; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Dai XY; NIHR Leicester Biomedical Research Centre, Leicester, UK.
Kang CM; Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China.
Lu JB; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xu BM; Department of Vascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xu YJ; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xiao L; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Lu ZF; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Bai HL; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Hu YW; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Wang Q; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. ywhu0618@smu.edu.cn.

Cell Death Differ ; 26(9): 1670-1687, 2019 09.

Article em En | MEDLINE | ID: mdl-30683918

Assuntos

Aterosclerose/metabolismo; Autofagia/genética; Inflamação/metabolismo; Lipoproteínas LDL/metabolismo; Oxigenases de Função Mista/metabolismo; Proteínas Quinases/metabolismo; RNA Longo não Codificante/metabolismo; Adenina/análogos & derivados; Adenina/farmacologia; Animais; Aterosclerose/genética; Autofagossomos/metabolismo; Autofagossomos/ultraestrutura; Autofagia/efeitos dos fármacos; Proteína 7 Relacionada à Autofagia/genética; Proteína 7 Relacionada à Autofagia/metabolismo; Sequenciamento de Cromatina por Imunoprecipitação; Células Endoteliais da Veia Umbilical Humana; Humanos; Inflamação/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Microscopia Eletrônica de Transmissão; Oxigenases de Função Mista/antagonistas & inibidores; Oxigenases de Função Mista/genética; Proteínas Quinases/genética; RNA Longo não Codificante/genética; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética; Serina-Treonina Quinases TOR/genética; Serina-Treonina Quinases TOR/metabolismo; Análise Serial de Tecidos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Autofagia / Aterosclerose / RNA Longo não Codificante / Oxigenases de Função Mista / Inflamação / Lipoproteínas LDL Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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