The Toxin-Antidote Model of Cytoplasmic Incompatibility: Genetics and Evolutionary Implications.
Trends Genet
; 35(3): 175-185, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30685209
ABSTRACT
Wolbachia bacteria inhabit the cells of about half of all arthropod species, an unparalleled success stemming in large part from selfish invasive strategies. Cytoplasmic incompatibility (CI), whereby the symbiont makes itself essential to embryo viability, is the most common of these and constitutes a promising weapon against vector-borne diseases. After decades of theoretical and experimental struggle, major recent advances have been made toward a molecular understanding of this phenomenon. As pieces of the puzzle come together, from yeast and Drosophila fly transgenesis to CI diversity patterns in natural mosquito populations, it becomes clearer than ever that the CI induction and rescue stem from a toxin-antidote (TA) system. Further, the tight association of the CI genes with prophages provides clues to the possible evolutionary origin of this phenomenon and the levels of selection at play.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Bacterianas
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Wolbachia
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Citoplasma
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Doenças Transmitidas por Vetores
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article