STAT3 rs4796793 contributes to lung cancer risk and clinical outcomes of platinum-based chemotherapy.
Int J Clin Oncol
; 24(5): 476-484, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-30689078
ABSTRACT
BACKGROUND:
Signal transducer and activator of transcription (STAT) 3 plays a vital role in carcinogenesis and drug response. Platinum-based chemotherapy is the first-line treatment for lung cancer patients, especially those in advanced stages. In the present study, we investigated the association of STAT3 polymorphism rs4796793 with lung cancer susceptibility, platinum-based chemotherapy response, and toxicity.METHODS:
A total of 498 lung cancer patients and 213 healthy controls were enrolled in the study. 467 of them received at least 2-cycle platinum-based chemotherapy. Unconditional logistical regression analysis was used to assess the associations.RESULTS:
STAT3 rs4769793 G allele carriers had an increased susceptibility of lung cancer [additive model adjusted OR (95% CI) 1.376 (1.058-1.789), P = 0.017; recessive model adjusted OR (95% CI) 1.734 (1.007-2.985), P = 0.047]. Rs4769793 was not significantly associated with platinum-based chemotherapy response in lung cancer patients. STAT3 rs4796793 was associated with an increased risk of severe overall toxicity [additive model adjusted OR (95% CI) 1.410 (1.076-1.850), P = 0.013; dominant model adjusted OR (95% CI) 1.638 (1.091-2.459), P = 0.017], especially hematological toxicity [additive model adjusted OR (95% CI) 1.352 (1.001-1.826), P = 0.049].CONCLUSIONS:
STAT3 rs4796793 may be considered as a potential candidate biomarker for the prediction of susceptibility and prognosis in Chinese lung cancer patients. However, well-designed studies with larger sample sizes are required to verify the results.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article